SEARCH FOR ANTITUMOR COMPOUNDS .12. BIOLOGIC STUDIES - ANTITUMOR PROPERTIES OF 12 NEW 1-NITRO-9-ALKYLAMINOALKYLAMINOACRIDINES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 25  (2) , 253-262
Abstract
The results of a study of the antitumor activity of 12 1-nitro-9-alkylaminoalkylaminoacridines in mice bearing sarcoma (Sa) 180 were presented. Only 1 of these compounds, C-846 [isopropyl derivative] was active in the Sa 180 test. The activity of 5 other compounds tested (C-845 [ethyl derivative], C-848 [isopentyl derivative], C-852 [benzyl derivative], C-865 [methyl derivative] and C-866 [n-propyl derivative]) required further elucidation in new Sa 180 tests. The remaining 6 compounds were inactive. Other general effects in mice bearing Sa 180 and aspects of the structure-activity relationship were discussed.

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