The Clinical Use of Chlorambucil

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Abstract
CHLORAMBUCIL (P-[di-2-chloroethylamino]-phenylbutyric acid, or CB 1348) is an analogue of nitrogen mustard that may be administered orally. There have been several reports attesting to its usefulness in the treatment of patients with lymphoma and chronic lymphocytic leukemia.1 2 3 4 5 A considerable experience has been accumulated at the Memorial Center for Cancer and Allied Diseases with nitrogen mustard6 and triethylene melamine,7 and it was against this background that the study of the use of chlorambucil was made.To evaluate the use of chlorambucil, particular attention was paid to specific points of administration and response such as the value of maintenance therapy, combination therapy . . .