Ein Beitrag zum Verhalten des Trimethylamins und des Trimethylaminoxyds im Stoffwechsel

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Abstract
Most of the trimethylamine ingested by man, dog, and rabbit is excreted in the urine as the oxide ((CH3)3NO), the ratio of the amine to the oxide being 1:20-1:50. Rats given 14.7 mg. N as the amine/day for 4 days convert 19% to the oxide; guinea pigs given 36.75 mg. N as the amine for 2 days convert 41% to the oxide. When similar amts. of (CH3)3N are injd. subcut., 11% is recovered as the oxide in the urine of the rat, and 32.5% in the urine of the guinea pig. Part of the amine is recovered unchanged and apparently none is converted to urea. Inj. of (CH3)3N does not cause an increase in the conc, of the compound in the animal organs. Hashed organs or aqueous extracts of the organs do not oxidize the amine to the oxide, nor does perfusion through surviving animal livers. Liver hash and extracts of liver completely reduce the oxide to the amine, but perfusion through the liver does not bring about the reaction. Perfusion of livers with (CH3)3N, but not with the oxide, induces urea formation. Yeast cannot convert the amine to the oxide, but may reduce the oxide to the amine.

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