Bioassay and Radioimmunoassay of Gastrin and Significance of Gastrin Degradation Products
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 9 (3) , 166-172
- https://doi.org/10.1159/000127936
Abstract
Inactivation of gastrin was studied in vitro by incubation with a high-speed supernatant fraction of rat small bowel mucosa and in vivo by perfusing gastrin through the small bowel vascular bed in anesthetized dogs. There was a highly significant loss in the bioactivity of gastrin but no significant change in its immunoreactivity. Gastrin was inactivated by a subtle chemical change which rendered the molecule biologically inactive yet left its immunoreactivity unimpaired.This publication has 1 reference indexed in Scilit:
- Immunologic Studies of Adrenocorticotropic Hormone (ACTH): Dissociation of Biologic and Immunologic ActivitiesJournal of Clinical Endocrinology & Metabolism, 1965