Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat

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Abstract
The effects of several bacterial endotoxins on body temperature and resting oxygen consumption (.ovrhdot.VO2) were compared in normal rats. Low doses (0.05 mg/kg, i.m.) of 0127:B8 phenol-extracted endotoxin caused significant increases in both parameters. Maximal febrile responses (+1.6.degree. C) occurred at a dose of 0.05 mg/kg, but higher doses produced smaller effects. The maximal increase in .ovrhdot.VO2 (17%) occurred at doses of 0.5-1.0 mg/kg. A TCA extract of the same strain of endotoxin elicited a similar pattern of responses but was less potent than the phenol extract, whereas another endotoxin 026:B6 (TCA extract) was much less potent. The data illustrate the importance of constructing dose-response curves when comparing different endotoxins and indicate that in the rat, oxygen consumption provides a useful index of the response to pyrogens.

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