Effect of Total Body X-Irradiation on Glutathione Levels in Rats.

Abstract
Rats exposed to 500 r total body X-irradiation showed a rise in blood reduced glutathione values 48 to 72 hrs. post irradiation. However, between 6 and 19 days post irradiation a marked drop in these values occurred. Hematocrit values generally decreased, but often irregularly relative to glutathione. Nine of 23 rats biopsied 6 to 19 days post irradiation showed low liver glutathione values. These animals had blood glutathione levels of 10 mg. % or less.

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