Protein‐free models for the proton‐coupled reduction of haemoproteins

Abstract
Reduction of the bis-pilocarpate—haemin complex at pH ⩾ 10 involves the simultaneous uptake of an electron by the Fe(III) ion and a proton by the pendant alkoxide group of an axial ligand. This provides a protein-free model for reactions such as the proton-coupled reduction of cytochromes which involve cooperative Coulombic interaction between two non-bonded sites.