Potent Thrombin Inhibitors That Probe the S1‘ Subsite: Tripeptide Transition State Analogues Based on a Heterocycle-Activated Carbonyl Group
- 1 January 1996
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 39 (16) , 3039-3043
- https://doi.org/10.1021/jm9603274
Abstract
No abstract availableThis publication has 12 references indexed in Scilit:
- Cyclotheonamide derivatives: Synthesis and thrombin inhibition. Exploration of specific structure-function issuesBioorganic & Medicinal Chemistry, 1995
- Synthesis and Structure-Activity Relationships of Peptidyl .alpha.-Keto Heterocycles as Novel Inhibitors of Prolyl EndopeptidaseJournal of Medicinal Chemistry, 1994
- Direct thrombin inhibitors in cardiovascular medicine.Circulation, 1994
- α-Ketothiazole inhibitors of prolyl endopeptidaseBioorganic & Medicinal Chemistry Letters, 1994
- Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.Proceedings of the National Academy of Sciences, 1993
- Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitorsJournal of Medicinal Chemistry, 1992
- The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationshipsProtein Science, 1992
- Design, synthesis, and kinetic evaluation of a unique class of elastase inhibitors, the peptidyl .alpha.-ketobenzoxazoles, and the x-ray crystal structure of the covalent complex between porcine pancreatic elastase and Ac-Ala-Pro-Val-2-benzoxazoleJournal of the American Chemical Society, 1992
- ThrombinPublished by Springer Nature ,1992
- The coagulation cascade: initiation, maintenance, and regulationBiochemistry, 1991