ASSAY OF ADRENAL CORTICAL EXTRACTS IN ADRENALECTOMIZED RATS EXPOSED TO COLD1

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Abstract
Expts. were made on an assay method for adrenal cortical extracts involving the maintenance of the body temp. of adrenalectomized young rats exposed to an environmental temp. of 1[degree] C. A single dose of 0.05 ml. of one commercial extract administered immediately before exposure significantly decreased the rate of fall of the body temp. A 2d commercial extract was 1/6 as active, 0.3 ml. being required for a comparable effect. Protection was afforded when 0.2 ml. was given 3 hrs. prior to exposure, but no effect was observed when large amts. were injd. after a fall in body temp. had occurred. Certain advantages and difficulties of this method of assay are discussed.

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