HEPATOSPLENOGRAPHY WITH THORIUM DIOXIDE SOL

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Abstract
Although the Council on Pharmacy and Chemistry of the American Medical Association in December, 1932, reported unfavorably on the intravenous use of thorium dioxide,1it did not entirely condemn its use but urged great caution therein. The study of the Council did not reveal serious ill effects, so far as clinical experience was concerned, with the use of thorium dioxide sol administered intravenously, but it brought forward the possibilities of latent radioactivity, remote partial conversion of the metal into more radioactive mesothorium and radiothorium and sensitization of tissues to x-ray or radium therapy. These possibilities are all due to the facts that thorium dioxide is a heavy metal with some radioactivity and that after being phagocytosed by the reticulo-edothelial cells of the body it is extremely slowly excreted from the body, probably requiring years to be completely removed. Although we had used this metal for roentgenographic demonstration of structural

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