Practical Closed-Loop Insulin Delivery

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Abstract
A practical closed-loop system of insulin delivery consisting of hourly blood glucose determinations using glucose oxidase reagent strips and an i.v. infusion of insulin controlled by a commonly available controller was evaluated. In 25 insulin-dependent diabetic subjects, this system was successful in achieving and maintaining near euglycemia (blood glucose, 101 .+-. 2 mg/dl, mean .+-. SE) in the fasting state between 0200 and 0800 h. This system may be useful in the management of insulin-dependent diabetic patients in various hospital settings. Also, in 10 subjects treated subsequently using a continuous s.c. insulin infusion, the mean hourly insulin infusion rate using the described system correlated well (r = 0.92) with the optimal overnight basal rate needed during continuous s.c. insulin infusion therapy.