STUDIES OF BIOCHEMICAL LESION EXPERIMENTAL TUBERCULOSIS IN MICE .4. EFFECT OF TUBERCLE BACILLI GROWN IN VIVO ON RESPIRATORY CHAIN ENZYMES

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Abstract
The effect of heat-killed tubercle bacilli grown in vivo on the activities of the respiratory chain enzymes was studied. The bacteria grown in vivo were more toxic for mice and more inhibitory to the succinate oxidase and succinate-cytochrome c reductase systems in liver than those cultured in vitro. Succinate dehydrogenase and cytochrome oxidase were not affected by the injection of either in vivo grown bacilli or those cultured in vitro. The inhibitory effect of bacilli grown both in vivo and in vitro on these enzymic systems was noted only in vivo. The lesion brought about by the injection of dead in vivo grown bacilli into normal mice is the same as that produced by the intoxication with cord factor or in the course of infection with living tubercle bacilli.

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