Forelimb malformation in rats caused by cyclophosphamide
Open Access
- 1 January 1984
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 55 (6) , 643-646
- https://doi.org/10.3109/17453678408992414
Abstract
A single dose of cyclophosphamide (20 mg/kg) was administered to female rats on Day 12 of gestation. Fetuses were collected at 24-h intervals from gestation Day 18 to 20. Gross malformations of the forelimb were observed, notably micromelia, oligodactyly, brachydactyly and adactyly. Specimens stained with Alizarin red-s and Alcian blue revealed postaxial skeletal deformities. Chronological histochemical investigations revealed delay in the ossification of the radius and completely unossified ulna; the end results showed the ulna to be more affected than the radius.This publication has 8 references indexed in Scilit:
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