Dexamethasone, Aldosterone and Kallikrein Release by Isolated Rat Kidney
- 1 August 1981
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 61 (2) , 241-243
- https://doi.org/10.1042/cs0610241
Abstract
1. The effect of d-aldosterone and dexamethasone on kallikrein release was studied in the isolated rat kidney perfused with modified Krebs-Henseleit buffer. 2. Animals received d-aldosterone or dexamethasone (10 μg/100 g body weight) daily for 3 days. Their isolated kidneys were then perfused with the same steroids at rates of 2.0–2.5 μg/min for 30 min. 3. Dexamethasone increased kallikrein release significantly (P < 0.001) both in urine and in venous outflow. 4. d-Aldosterone had no significant effect on kallikrein release, either in urine or in venous outflow.Keywords
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