THE INFLUENCE OF NEUTRAL SODIUM-SALT SOLUTIONS ON CHEMICAL STIMULATION

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Abstract
[Other investigators have shown that] a frog''s sartorius, immersed in a pure isotonic Na-salt solution for a short time, becomes increasingly responsive to the chemical stimulation of an isotonic NaCl solution containing 5 millimols KCl per liter to a degree depending on the nature of the anions and corresponding to their relative positions in the lyo-tropic series; namely, NaCl < NaBr < NaNO3 < NaI < NaCNS. [The present study shows that], for any given Na-salt solution the increase in irritability is a direct function of its conc. The min. conc. of each salt necessary to produce a given increase depends, in general, on its relative position in the lyotropic series. The change of irritability in any pure Na-salt solution increases rapidly with the duration of immersion in that solution. The rapidity with which the max. response is reached depends again on the nature of the anions, and follows the lyotropic order. The action of any given Na-salt solution is antagonized by HC1 and chlorides of the alkali earth metals in the order: SrCl2 < MgCl2 < CaCl2 < HCl. The min. conc. of any of these antagonizing substances for each Na-salt depends again on the nature of the anion of the Na-salt. increasing in the lyotropic order as above. The skeletal muscle is more susceptible to chemical stimulation at low temp. and the sensitizing action of all the Na-salt solutions (except NaCl) is greater at low temp. It is suggested that these Na-salt solutions tend to facilitate or increase the dispersion of certain colloidal constituents of the plasma membrane.

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