Long-Term Co-Trimoxazole Treatment of Chronic Salmonella Carriers

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Abstract
Long-term co-trimoxazole treatment (4–6 months) was tried in 7 chronic carriers of mainly Salmonella typhi and S. paratyphi B. No one had positive faecal cultures during treatment. Four faecal carriers were followed-up with regular cultures for at least 1 year after treatment and 3 of them remained negative. Long-term co-trimoxazole treatment seems to be well tolerated also in very old patients and may be worth trying also in cases where other antibiotics have failed.

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