Biosynthesis of 17β-oestradiol in human breast carcinoma tissue and a novel method for its characterization
- 1 April 1975
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 31 (4) , 429-433
- https://doi.org/10.1038/bjc.1975.82
Abstract
Conversion of 7alpha3H-testosterone to 17beta-oestradiol by human mammary carcinoma tissue in vitro has been demonstrated. It was characterized unequivocally by conversion to 17beta-oestradiol-3-sulphate upon incubation with adenosine-3'-phosphate-5'-phosphosulphate and the highly specific enzyme oestrogen sulphotransferase.Keywords
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