Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier
Open Access
- 4 August 2003
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 162 (3) , 489-498
- https://doi.org/10.1083/jcb.200303039
Abstract
Nodes of Ranvier are specialized, highly polarized axonal domains crucial to the propagation of saltatory action potentials. In the peripheral nervous system, axo–glial cell contacts have been implicated in Schwann cell (SC) differentiation and formation of the nodes of Ranvier. SC microvilli establish axonal contact at mature nodes, and their components have been observed to localize early to sites of developing nodes. However, a role for these contacts in node formation remains controversial.Keywords
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