Turnover of Inositol Phospholipids and Signal Transduction
- 21 September 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 225 (4668) , 1365-1370
- https://doi.org/10.1126/science.6147898
Abstract
Various extracellular informational signals such as those from a group of hormones and some neurotransmitters appear to be passed from the cell surface into the cell interior by two routes, protein kinase C activation and Ca2+ mobilization. Both routes usually become available as the result of an interaction of a single ligand and a receptor and act synergistically to evoke subsequent cellular responses such as release reactions. The signal-dependent breakdown of inositol phospholipids, particularly phosphatidylinositol bisphosphate, now appears to be a key event for initiating these processes.Keywords
This publication has 101 references indexed in Scilit:
- Synergistic action of protein kinase C and calcium for histamine release from rat peritoneal mast cellsBiochemical and Biophysical Research Communications, 1984
- Insulin secretion: Combined effects of phorbol ester and A23187Biochemical and Biophysical Research Communications, 1983
- A possible role of protein kinase C in signal-induced lysosomal enzyme releaseBiochemical and Biophysical Research Communications, 1983
- Aldosterone secretion: Effect of phorbol ester and A23187Biochemical and Biophysical Research Communications, 1983
- Inhibitory action of adenosine 3′,5′-monophosphate on phosphatidylinositol turnover: Difference in tissue responseBiochemical and Biophysical Research Communications, 1982
- Inhibitory action of guanosine 3′,5′-monophosphate on thrombin-induced phosphatidylinositol turnover and protein phosphorylation in human plateletsBiochemical and Biophysical Research Communications, 1981
- Phospholipid turnover as a possible transmembrane signal for protein phosphorylation during human platelet activation by thrombinBiochemical and Biophysical Research Communications, 1980
- Concentrations and disappearance post mortem of polyphosphoinositides in developing rat brainBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967
- The biosynthesis of triphosphoinositide by rat brain in vitroBiochemical and Biophysical Research Communications, 1966
- The site of diphosphoinositide synthesis in rat liverBiochemical and Biophysical Research Communications, 1965