Lessons learnt from the synovial tissue response to anti-rheumatic treatment

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Abstract
There has been increased interest in studies on synovial tissue in recent years. This can be explained by technical developments and by the recognition of the synovium as the primary site of inflammation in patients with rheumatoid arthritis (RA) and other arthritides. Obviously, examination of peripheral blood and synovial fluid may provide insight into the production of soluble mediators as well as the dynamics of migration of inflammatory cells into different compartments. However, it has become clear that such studies yield only indirect information about the events in the synovium. Hence, there has been an upsurge in investigations of the pathological changes taking place in the rheumatoid synovium [1]. These studies have been used to provide more insight into the pathogenesis and to identify features which might be used for diagnostic purposes and to provide a prognosis [2].

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