HLA system and side effects of gold salts and D-penicillamine treatment of rheumatoid arthritis.
Open Access
- 1 December 1982
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 41 (6) , 599-601
- https://doi.org/10.1136/ard.41.6.599
Abstract
Among 67 patients with rheumatoid arthritis treated with gold salts (aurothiopropanol sulphonate) a significant correlation (p less than 10(-2)) was noted between gold toxic reactions, whatever their type, and the HLA antigens A1, B8, Cw7, and DR3. Forty-two patients were genotyped, and a correlation was observed between gold side effects and the haplotype A1 Cw7 B8 DR3 (p less than 10(-2), RR = 8.0). In addition 3 out of 4 cases of renal intolerance to D-penicillamine were observed in patients possessing the Cw7 B8 DR3 haplotype.This publication has 7 references indexed in Scilit:
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