Nea, a New Blood Group Antigen in Finland

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Abstract
A previously unrecognized blood group antigen is described. The antigen is different from many rare blood group antigens, is inherited as an autosomal dominant character and is not closely linked to the established blood group systems nor to several other polymorphic blood markers. The antigen is well developed at birth. About 5% of Finns have this antigen. Only 1 donor in 502 Swiss blood donors and 2 unrelated donors in 395 Swedish blood donors were positive for the antigen. The antigen is provisionally called Nea and the respective antibody anti-Nea. At least 3 Ne(a+) blood units were given to a patient on different occasions before anti-Nea was detected in compatibility tests. Since the discovery of the 1st anti-Nea, 3 additional examples of this antibody were identified in serum from multitransfused patients. Anti-Nea is capable of shortening the in vivo survival of transfused incompatible Ne(a+) cells.
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