Two antitumour ruthenium(III) complexes showing selectivity in their binding towards poly(dG)·poly(dC) and poly(dA)·poly(dT)
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 15,p. 1741-1742
- https://doi.org/10.1039/cc9960001741
Abstract
The antitumour-active complexes trans-Him[RuIIICl4(im)2](Him = imidazole) and trans-Hind[RuIIICl4(ind)2](Hind = indazole) bind at a higher binding rate to poly(dG)·poly(dC), compared to poly(dA)·poly(dT); the covalent binding to the nucleobases requires a preceding aquation of the compounds, similar to cisplatin.Keywords
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