Re‐evaluation of 1,2‐dimethylhydrazine in the mouse bone marrow micronucleus assay: Observation of a positive response

1 January 1987

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 9 (2) , 177-181
https://doi.org/10.1002/em.2860090208

Abstract

1,2‐Dimethylhydrazine showed dose‐related clastogenic activity in the mouse bone marrow micronucleus assay following intubation of an aqueous solution of the dihydrocholoride salt (10 and 50 mg/kg, 24 h sampling). These data counter earlier reports of the inactivity of this material in a rat and a mouse micronucleus assay, following its intraperitoneal injection. In the present study, 2,000 polychromatic erythrocytes were assessed per animal. However, had only 300 cells been assessed for micronucleated polychromatic erythrocytes, it is shown that a negative result could have been recorded. This may explain the earlier and negative results.

Keywords

This publication has 10 references indexed in Scilit:

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