Probe, VK5B, is located in the same interval as the autosomal dominant adult polycystic kidney disease locus, PKD1
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 84 (3) , 286-288
- https://doi.org/10.1007/bf00200577
Abstract
The polymorphic DNA probe VK5B (D16S94) was mapped by genetic linkage in families from the Centre d'Etude de Polymorphisme Humain (CEPH) as being in the same interval as the autosomal dominant adult polycystic kidney disease locus (PKD1). The maximum likelihood estimate of the genetic location of VK5B using multipoint linkage analysis was 9.6cM proximal to {ie286-01} (D16S85) and 5.4cM distal to CRI-0327 (D16S63), in males. The VK5B probe may be useful in PKD1 families for prenatal and presymptomatic diagnosis of the disease. Additional typing of PKD1 families is required to determine whether the location of VK5B is distal or proximal to (PKD1).Keywords
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