A TAD Further: Exogenous Control of Gene Activation

Publisher Website

1 January 2007

journal article
review article
Published by American Chemical Society (ACS) in ACS Chemical Biology

Vol. 2 (1) , 62-75
https://doi.org/10.1021/cb600463w

Abstract

No abstract available

Keywords

COACTIVATOR: A PROTEIN THAT INTERACTS WITH THE TRANSCRIPTIONAL ACTIVATION DOMAIN OF A DNA-BOUND TRANSCRIPTIONAL ACTIVATOR AND PARTICIPATES IN THE GENE-ACTIVATION PROCESS.
DNA BINDING DOMAIN (DBD): ONE OF THE TWO KEY DOMAINS OF AN ACTIVATOR ATF, THE DBD PROVIDES THE GENE-TARGETING SPECIFICITY OF THE MOLECULE.
TRANSCRIPTIONAL ACTIVATION DOMAIN (TAD): ONE OF THE TWO KEY DOMAINS OF AN ACTIVATOR ATF, THE TAD DICTATES THE TIMING AND EXTENT OF TRANSCRIPTIONAL UP-REGULATION THROUGH BINDING INTERACTIONS WITH ONE OR MORE COMPONENTS OF THE TRANSCRIPTIONAL MACHINERY.

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