The Isolation of Tetrahydroxy Bile Acids as Methyl Esters from Human Urine and their Characterization by1H- and13C-Nuclear Magnetic Resonance Spectroscopy
- 1 January 1984
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 365 (1) , 479-484
- https://doi.org/10.1515/bchm2.1984.365.1.479
Abstract
Treatment with phenobarbital causes an increased urinary excretion of tetrahydroxylated bile acids in patients suffering from intrahepatic cholestasis. The main components were isolated from urine by means of column and TLC and were studied as methyl esters by CMR spectroscopy. The main components evidently are 1.beta.-, 6.alpha.- and 6.beta.-hydroxylated derivatives of cholic acid.This publication has 9 references indexed in Scilit:
- Hydroxylation of cholic, chenodeoxycholic, and deoxycholic acids in patients with intrahepatic cholestasisPublished by Elsevier ,2021
- High resolution nuclear magnetic resonance spectroscopy of bile salts: individual proton assignments for sodium cholate in aqueous solution at 400 MHz.Journal of Lipid Research, 1982
- Urinary bile acids during development of recurrent cholestasis of pregnancyEuropean Journal of Clinical Investigation, 1979
- Urinary bile acids in late pregnancy and in recurrent cholestasis of pregnancyEuropean Journal of Clinical Investigation, 1979
- Bile acid profiles in urine of patients with liver diseasesEuropean Journal of Clinical Investigation, 1979
- Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometryJournal of Lipid Research, 1977
- Steroid Metabolism in Rats Given [1-2H2]Ethanol. Oxidoreduction of Isomeric 3-Hydroxycholanoic Acids and Reduction of 3-Oxo-4-cholenoic AcidEuropean Journal of Biochemistry, 1972
- A Versatile Method for Analysis of Bile Acids in PlasmaAnalytical Letters, 1972