Development and validation of therapeutically relevant multi-gene biomarker classifiers.
Open Access
- 15 June 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 97 (12) , 866-867
- https://doi.org/10.1093/jnci/dji168
Abstract
In June 2004 Ma et al. ( 1 ) described a two-gene expression ratio that they claimed accurately predicted clinical outcome of early-stage breast cancer patients treated with adjuvant tamoxifen monotherapy. In the current issue of this journal, Reid et al. ( 2 ) reported their failure to confirm the usefulness of the two-gene expression ratio on independent data. I will attempt to try to provide possible explanations for the inconsistency of results of the two studies and to draw some general conclusions.Keywords
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