NON-PROTEIN-BOUND OESTROGENS IN PLASMA AND URINARY EXCRETION OF UNCONJUGATED OESTROGENS IN MEN

Publisher Website
Google Scholar
Abstract
Unconjugated estrone [E1] and unconjugated estradiol-17.beta. [E2] were measured in 24 h urine specimens from 20 normal men. The concentrations of non-protein-bound E1 and non-protein-bound E2, in samples of blood obtained from these subjects during the time in which the urine was collected, were measured by equilibrium dialysis (using a correction for plasma dilution). The mean excretion of unconjugated E1 (0.44 .+-. 0.36 nmol/24 h, mean .+-. SD) was significantly greater (P < 0.01) than that of unconjugated E2 (0.20 .+-. 0.13 nmol/24 h). The concentrations of non-protein-bound E1 and non-protein-bound E2 in plasma were 5.52 .+-. 2.69 pmol/l and 2.42 .+-. 0.73 pmol/l, respectively. There was no correlation between the quantity of unconjugated E1 excreted and the concentration of non-protein-bound E1 in plasma (r [correlation coefficient] = 0.27) nor between the quantity of unconjugated E2 in the urine and the concentration of non-protein-bound E2 in plasma (r = 0.05). Therefore, in normal men, estimation of unconjugated E1 or E2 in urine provides no guide to the concentration of the corresponding non-protein-bound estrogen in plasma.

This publication has 9 references indexed in Scilit: