BISMUTH TOXICITY IN MAN .1. BISMUTH BLOOD AND URINE LEVELS IN PATIENTS AFTER ADMINISTRATION OF A BISMUTH PROTEIN COMPLEX (BICITROPEPTIDE)

  • 1 January 1979
    • journal article
    • research article
    • Vol. 26  (2) , 383-389
Abstract
In the course of a double-blind clinical trial of treatment involving a Bi protein complex (Bicitropeptide [a peptic ulcer therapeutic agent]), an antacid and placebo, blood samples (33 patients) and urine samples (43 patients) were collected for Bis analysis from patients on Bi therapy at the beginning of the trial (wk 0) and at wk 3 and 6. Base line blood (2-11 ng/l) and urine (2-29 ng/l) values were not zero and appeared to have reached saturation values in many cases after 3 wk (blood, 4-33 ng/l and urine, 60-600 ng/l). After 6 wk, blood values were 5-20 ng/l and urine values 63-780 ng/l. These blood and urine levels are evidently not associated with significant toxicity in man.

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