Brain Protection by Phenobarbitone in Very Low Birthweight (VLBW) Prematures - A Controlled Trial
- 13 March 1985
- journal article
- clinical trial
- Published by Georg Thieme Verlag KG in Klinische Padiatrie
- Vol. 197 (02) , 170-171
- https://doi.org/10.1055/s-2008-1033960
Abstract
Prematures with birthweights below 1500 g were enrolled in a randomized controlled study to evaluate the effect of phenobarbitone on early periventricular haemorrhage (PVH) and late handicap due to neuronal damage. PVH was diagnosed by ultrasound in 8 of 25 in the treatment group and in 14 of 27 in the control group. So far, 22 infants have been examined at the age of 9 months; 3 of 9 treated and 4 of 13 control infants were neurologically handicapped. These preliminary results suggest a beneficial effect of phenobarbitone. The study continues to establish long-term effects.Keywords
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