Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype.
- 1 February 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (2) , 966-969
- https://doi.org/10.1073/pnas.75.2.966
Abstract
The complete amino acid sequence of the .alpha.2 H chain of a human Ig (immunoglobulin) A2 of the A2m(2) allotype was determined and was compared to the sequence of the .alpha.1 chain of the human IgA1 subclass. The characteristic differences between the .alpha.1 and .alpha.2 chains are greatest in the hinge region and in the location and number of the oligosaccharides. Apart from the duplication in the hinge region of .alpha.1 and the deletion in .alpha.2, there are 23 amino exchanges in the constant (C) regions of the 2 chains. Accepted mutations are related to the surface accessibility of the residues and the proximity of carbohydrate. Human IgA and IgG subclasses apparently arose late in evolution and reflect similar mutational pressures.This publication has 18 references indexed in Scilit:
- On the location of palindromes in immunoglobulin genes.Proceedings of the National Academy of Sciences, 1977
- Location and structural significance of the oligosaccharides in human Ig-A1 and IgA2 immunoglobulins.Proceedings of the National Academy of Sciences, 1977
- Crystallographic structure studies of an IgG molecule and an Fc fragmentNature, 1976
- Structure and function of the constant regions of immunoglobulinsQuarterly Reviews of Biophysics, 1976
- The First Isoallotype of Human IgA ProteinsScandinavian Journal of Immunology, 1976
- Neisseria gonorrhoeae and Neisseria meningitidis : Extracellular Enzyme Cleaves Human Immunoglobulin AScience, 1975
- Partial amino acid sequence of an IgA2 human immunoglobulin heavy chainBiochimica et Biophysica Acta (BBA) - Protein Structure, 1975
- Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteinsBiochemistry, 1974
- Characterization of a disulfide bridge linking the J chain to the α chain of polymeric immunoglobulin ABiochemical and Biophysical Research Communications, 1973
- Three Variable-Gene Pools common to IgM, IgG and IgA ImmunoglobulinsNature, 1970