Diayangambin Exerts Immunosuppressive and Anti-Inflammatory Effectsin vitroandin vivo

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Abstract
In this study, the furofuran lignan (+)-diayangambin [tetrahydro-1,4-bis(3,4,5-trimethoxyphenyl)-(1R)-1α,3aβ,4α,6aβ-1H,3H-furo [3,4-c]furan] was evaluated in vitro and in vivo for its immunomodulatory and anti-inflammatory efficacy. Human mononuclear cell proliferation was inhibited by diayangambin with an IC50 value of 1.5 (0.5 - 2.8) μM. In addition, the compound reduced for 40.8 % prostaglandin E2 generation in stimulated RAW 264.7 macrophage cell line at 10 μM. In vivo, a clear reduction of ear swelling was observed when diayangambin (40 mg/kg) was administered orally to 2,4-dinitrofluorobenzene-treated mice. The inhibition of swelling was associated with a reduction of leukocyte infiltration determined as myeloperoxidase activity. In the carrageenan mouse paw edema model, diayangambin significantly suppressed inflamed paw volume and prostaglandin E2 levels. Our findings indicate the potential interest of diayangambin in the treatment of immune and inflammatory responses.

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