KF4939, a New Anti-Platelet Agent, Inhibits Activation of Phospholipase C and A2 in Rabbit Platelets
Open Access
- 1 January 1985
- journal article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 39 (1) , 106-107
- https://doi.org/10.1254/jjp.39.108
Abstract
Effect of KF4939 on activation of phospholipase C and A2 was examined by using rabbit platelets prelabelled with [14C]-arachidonic acid. The results showed that KF4939 inhibited the activation of the two phospholipases, separately. The inhibition of phospholipase C activation is thought to be a possible mechanism of KF4939 to inhibit aggregation and secretion which are independent of the synthesis of cyclooxygenase products such as thromboxane A2.Keywords
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