Detection, clinical relevance and specific biological properties of disseminating tumour cells
Top Cited Papers
- 1 May 2008
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 8 (5) , 329-340
- https://doi.org/10.1038/nrc2375
Abstract
Most cancer deaths are caused by haematogenous metastatic spread and subsequent growth of tumour cells at distant organs. Disseminating tumour cells present in the peripheral blood and bone marrow can now be detected and characterized at the single-cell level. These cells are highly relevant to the study of the biology of early metastatic spread and provide a diagnostic source in patients with overt metastases. Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment.Keywords
This publication has 118 references indexed in Scilit:
- Systemic Spread Is an Early Step in Breast CancerCancer Cell, 2008
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- Metastasis: recent discoveries and novel treatment strategiesPublished by Elsevier ,2007
- Primary systemic therapy does not eradicate disseminated tumor cells in breast cancer patientsBreast Cancer Research and Treatment, 2007
- Detection of Mammaglobin A-mRNA-positive circulating tumor cells in peripheral blood of patients with operable breast cancer with nested RT-PCRClinical Biochemistry, 2006
- A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementationCancer, 2006
- Detection of cytokeratin-positive cells in the bone marrow of breast cancer patients undergoing adjuvant therapyBreast Cancer Research and Treatment, 2005
- Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancerCancer Cell, 2005
- The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrenceCancer, 2005
- Genetic heterogeneity of single disseminated tumour cells in minimal residual cancerThe Lancet, 2002