Synthesis and antihypertensive activity of some imidazoindole derivatives
- 1 November 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (11) , 1352-1354
- https://doi.org/10.1021/jm00233a022
Abstract
The synthesis of pyridino[1,2-.alpha.]imidazo[5,4-.beta.]indole (1) and thiazolo[3,2-.alpha.]imidazo[5,4-.beta.]indole (2) was achieved by phosphite reduction of 3-nitroso-6-phenylimidazo[1,2-.alpha.]pyridine and 5-nitroso-6-phenylimidazo[2,1-.beta.]thiazole. Compound 1 has shown strong antihypertensive activity in spontaneously hypertensive rats while compound 2 showed similar bioactivity in spontaneously hypertensive rats and in normotensive dogs. A tricyclic amino derivative, 3-amino-2-phenylimidazo[1,2-.alpha.]pyridine, which has structural resemblance to compound 1, showed no hypotensive activity.This publication has 2 references indexed in Scilit:
- Derivatives of Imidazole. II. Synthesis and Reactions of Imidazo[1,2-α]pyrimidines and Other Bi- and Tricyclic Imidazo Derivatives with Analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant ActivityJournal of Medicinal Chemistry, 1966
- Derivatives of Imidazole. I. Synthesis and Reactions of Imidazo[1,2-α]pyridines with Analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant ActivityJournal of Medicinal Chemistry, 1965