Manic Response to Levodopa Therapy

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Abstract
Levodopa (L-dopa) is at present the most effective drug for the treatment of Parkinson's disease1 but psychiatric side effects have been reported in 10 per cent of treated cases. These are confusional hallucinating symptoms, depression, anxiety and euphoric reactions.2 , 3 The pure manic response reported below occurred in a patient whose clinical symptoms of Parkinson's disease were reversed by treatment with L-dopa.Case ReportA 69-year-old retired drawbridge tender with an 8-year history of right-sided Parkinson tremor and rigidity was given small doses of L-dopa, which were gradually increased. There was no improvement until suddenly, when a dosage level of 3 . . .