The Effect of Unrelated Vaccines on the Localization of Paralysis in Mouse Encephalomyelitis

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Abstract
Conclusions Mice injected in a foreleg with pertussis vaccine alone or combined with precipitated diphtheria-tetanus toxoids were frequently paralyzed in the injected foreleg following infection with mouse encephalomyelitis virus. The frequency of paralysis in the inoculated extremity was 7 or more times greater than among the untreated controls. Precipitated diphtheria-tetanus toxoid had less effect and typhoid-paratyphoid vaccine had none. The injection of vaccines did not increase the frequency of paralysis, irrespective of location, but pertussis vaccine consistently shortened the period between the introduction of virus and the onset of paralysis.