Evolving Knowledge of Hemangiomas and Vascular Malformations

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Abstract
THE CHANGING understanding of hemangiomas and vascular malformations in many ways parallels the evolution of dermatology from a descriptive discipline to one of scientific discovery and explanation. Strawberry hemangiomas and port-wine stains, common vascular birthmarks that are clinically well defined with gustatory descriptions, have along with other vascular malformations been subject to new nomenclature, research into pathogenesis, improved diagnostic techniques, and advances in treatment. In this issue of the ARCHIVES, data reported by Blei et al1 raise important issues regarding possible genetic inheritance of hemangiomas and vascular malformations, identifying families with apparent autosomal dominant transmission of vascular lesions. The mechanisms of hemangioma and vascular malformation development remain uncertain. The work of Blei and colleagues provides an impetus for further scientific investigation.