Syntheses of antifungal isocoumarins. III. Synthesis and antifungal activity of 3-aryl-3,4-dihydro-4-substituted-isocoumarins.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 29 (12) , 3486-3493
- https://doi.org/10.1248/cpb.29.3486
Abstract
Various cis- and trans-3-aryl-3,4-dihydro-8-(hydroxy or methoxy)isocoumarin-4-carboxylic acids and their methyl esters were prepared. In addition, cis- and trans-3,4-dihydro-8-(hydroxy or methoxy)-4-hydroxyacetyl-3-phenylisocoumarins, cis- and trans-4-diazoacetyl-3,4-dihydro-8-methoxy-3-phenylisocoumarins, trans-4-acetoxyacetyl-3,4-dihydro-8-methoxy-3-phenylisocoumarin and trans-4-acetyl-3,4-dihydro-8-(hydroxy or methoxy)-3-phenylisocoumarins were prepared. All the 3,4-dihydroisocoumarins thus prepared were examined in vitro for antifungal activity. The introduction of a carboxyl, carbomethoxy, acetyl, diazoacetyl or hydroxyacetyl group at the 4-position of the 3,4-dihydroisocoumarin nucleus resulted in the disappearance of the activity.This publication has 1 reference indexed in Scilit:
- Syntheses of antifungal isocoumarins. II. Synthesis and antifungal activity of 3-substituted isocoumarins.CHEMICAL & PHARMACEUTICAL BULLETIN, 1981