A histone H1 protein in sea urchins is encoded by a poly(A)+ mRNA.

Publisher Website
Google Scholar
Abstract
Typical histone genes lack intervening sequences and encode small mRNAs (400-800 nucleotides) with short leader and trailer regions. Most histone mRNAs are not polyadenylylated but rather terminate in a highly conserved stem and loop structure. The early, late, and testis-specific histone genes of sea urchins, described to date, have this typical histone gene structure. We have identified an unusual H1 gene, H1-.delta., in sea urchins that encodes a poly(A)+ mRNA. This mRNA is one of a group of polyadenylylated transcripts homologous with H1 gene probes. The sequence of H1-.delta. has been determined. H1-.delta. encodes a different H1 protein. Although the temporal expression of H1-.delta. mRNA is similar to that of other late H1 (.beta. and .gamma.) mRNAs, its spatial distribution at the time of maximal accumulation is distinct and confirms that H1-.delta. is regulated differently than other H1 genes.