Comparison of Diatrizoate, Iopamidol, and Ioxaglate for Arterial Portography

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Abstract
Diatrizoate, opamidol and ioxaglate were compared in 5 normal dogs and in 5 dogs with presinusoidal cirrhosis and portal hypertension for arterial portography. After selective injection of 40 ml of each contrast agent in iodine concentration of 320 mg per ml into the superior mesenteric artery, portal vein blood samples were collected in 2-s intervals and the iodine concentrations determined using X-ray energy spectrometry. The highest I concentrations in the portal blood were found in both normal portal pressure and portal hypertension with ioxaglate, followed by iopamidol and diatrizoate in this order. Compared with diatrizoate, ioxaglate and iopamidol increased the peak portal blood iodine concentrations 45 and 22%, respectively. The use of ioxaglate in arterial portography should show the portal system at leasts as well as when a conventional contrast agent is used together with a vasodilator such as tolazoline.

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