Proliferative Cell Index in Endometrial Adenocarcinoma of Different Nuclear Grades

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Abstract
Proliferative cell indices (PCI) in 20 cases of endometrial adenocarcinoma were obtained by staining DNA polymerase a. The PCI ranged form 11.1 to 42.1, averaging 24.7 .+-. 8.7. Four cases of state III all exhibited fairly large PCI (30.4-32.9). In contrast, in 16 cases of stage I the values were spread over a wide range. InN 13 cases with histological grade (HG) 1 of stage I, larger PCI were obtained in the nuclear grade (NG) 2 group; the mean PCI values of HG 1-NG 1 and HG 1-0NG 2 were 16.5 .+-. 4.6 and 25.6 .+-. 5.2, respectively. Because of the good correlation between PCI and HG or NG, PCI may be useful as an additional prognostic factor in endometrial adenocarcinoma, especially in stage I cases.