Degradation and Elimination of Temik In Rats1

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Abstract
Oral administration of Temik½ (2-methyl-2-(methylthio) propionaldchyde O-(methylcarbamoyl)oxime) to rats resulted in approximately 80% of the dose being eliminated in the urine within 24 hours. An additional 4% of the dose was detected in the feces. Only a trace amount of Temik, per se, was found in the excreta, indicating a very rapid degradation of the carbamate within the animals. The following metabolites were isolated from the urine by extraction with chloroform and tentatively identified; (a) 2-methyl-2-(methylthio) propionaldoxime; (d) 2-methyl-2-(methylsulfinyl) propionaldoxime; (c) 2-methyl-2-(methylcarbamoyl) propionaldoxime; (d) 2-methyl-2-(methylsulfinyl) propionitrile; (e) 2-methyl-2-(methylsulfinyl) propionaldehyde O-(methylcarbamoyl) oxime and (g) 2-methyl-2-(methylsulfonyl) propionaldehyde O-(methylearbamoyl)-oxime. Approximately one-half of the metabolites in the urine could not be extracted into organic solvent and their identity was not determined. The methylsulfinyl derivative of Temik was excreted more slowly than the parent compound when given orally to rats.

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