A novel probe for imaging amyloid‐β: Synthesis of F‐18 labelled BF‐108, an Acridine Orange analog
- 9 May 2003
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 46 (8) , 765-772
- https://doi.org/10.1002/jlcr.716
Abstract
The synthesis of 3‐(2‐[18F]fluoroethyl)ethylamino‐6‐diethylaminoacridine ([18F]BF‐108), a potential positron‐labelled probe for imaging amyloid‐β is described. The precursor tosylate derivative was fluorinated with [18F]KF/ Kryptofix 222 in acetonitrile, and the crude product was purified by semi‐preparative HPLC to give the radiolabelled BF‐108. The radiochemical purity was >95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB). Copyright © 2003 John Wiley & Sons, Ltd.Keywords
This publication has 5 references indexed in Scilit:
- Proinflammatory effects of M-CSF and Aβ in hippocampal organotypic culturesNeurobiology of Aging, 2002
- Novel probes for imaging amyloid: Iodinated benzothiazole derivativesJournal of Labelled Compounds and Radiopharmaceuticals, 2001
- In vivo detection of amyloid plaques in a mouse model of Alzheimer's diseaseProceedings of the National Academy of Sciences, 2000
- Physical, Morphological and Functional Differences between pH 5.8 and 7.4 Aggregates of the Alzheimer's Amyloid Peptide A βJournal of Molecular Biology, 1996
- Thioflavine T interaction with synthetic Alzheimer's disease β‐amyloid peptides: Detection of amyloid aggregation in solutionProtein Science, 1993