Prediction of the Depressive Effects of Interferon Alfa Therapy by the Patient's Initial Affective State

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Abstract
The antiviral, immunomodulatory, and antiproliferative properties of interferon alfa give this cytokine potential therapeutic effects in chronic viral infections and cancers.1 A major limitation of interferon alfa therapy is its serious side effects, which include fever, headache, myalgias, sleep disturbances, fatigue, anorexia, and in some cases, mood disorders.1-4 Usually observed during late states of treatment, depressive symptoms are detrimental to the patient's quality of life and may justify adjustment or interruption of the treatment.3 Identifying patients at risk for these mood disturbances early in the treatment would permit the adoption of corrective measures.