Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding
- 15 January 1985
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 225 (2) , 523-527
- https://doi.org/10.1042/bj2250523
Abstract
In isolated rat adipocytes, tumour-promoting phorbol esters caused (1) dose-dependent stimulation of lipogenesis in the absence of insulin and (2) inhibition of the lipogenic effect of submaximal concentrations of insulin, but without affecting insulin binding. The possible involvement of protein kinase C in insulin action is discussed.Keywords
This publication has 19 references indexed in Scilit:
- Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.Published by Elsevier ,2021
- The Mechanism of Action of Insulin on Phospholipid Metabolism in Rat Adipose Tissue: Requirement for Protein Synthesis and a Carbohydrate Source, and Relationship to Activation of Pyruvate DehydrogenaseDiabetes, 1984
- Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenaseMolecular and Cellular Endocrinology, 1984
- Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.1984
- Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agentsBiochemical Journal, 1983
- Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cellsBiochemical Journal, 1980
- Inhibition of epidermal growth factor binding to surface receptors by tumor promotorsBiochemical and Biophysical Research Communications, 1979
- The effect of insulin on 32P1 incorporation into rat fat cell phospholipidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1974
- A Simple Free Fat Cell Bioassay for InsulinHormone and Metabolic Research, 1974
- The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissueBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1966