1,3-Asymmetric Induction in the Reaction of Organometallics to β-Hydroxy Ketones and β-Silyloxy Ketones
- 1 April 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 19 (4) , 597-600
- https://doi.org/10.1246/cl.1990.597
Abstract
High level of 1,3-asymmetric induction was realized in the reaction between β-hydroxy ketones and triisopropoxytitanium reagents to give anti-1,3-diols possessing tertiary alcohols. To the contrary, syn-1,3-diols were obtained by the addition reaction of organometallics to β-t-butyldimethylsilyloxy ketones.Keywords
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