The temperature dependence of halothane‐induced contractures of skeletal muscle

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Abstract
Frog muscles bathed in solutions equilibrated with 0.5%–2.0% halothane develop large contractures when cooled to 2–4°C. These halothane‐cooling contractures (HCC) are dose dependent and reproducible; they are potentiated by lidocaine (5 mM), abolished by procaine (5‐mM), and partially inhibited by procainamide (5 mM) or sodium salicylate (2 mM). The HCC provides a simple model system for investigating the effects of low halothane concentrations on Ca homeostasis and contractility in skeletal muscle.