Ticonazole, a New Imidazole-Antifungal Agent for the Treatment of Dermatomycoses
- 1 January 1983
- journal article
- research article
- Published by S. Karger AG in Dermatology
- Vol. 166 (Suppl. 1) , 1-7
- https://doi.org/10.1159/000249907
Abstract
Tioconazole is a new imidazole antifungal agent with broad-spectrum activity. Its in vitro activity against common dermal pathogens is generally better than miconazole by a factor of 2–8. This activity is paralleled by good topical efficacy in a guinea pig dermatomycosis model. Pharmacokinetic studies in animals have demonstrated minimal systemic exposure following dermal application. Acute general pharmacology studies have shown that the compound is well tolerated in animals and unlikely to produce side-effects in man.Keywords
This publication has 2 references indexed in Scilit:
- Antifungal Activity of Tioconazole (UK-20,349), a New Imidazole DerivativeAntimicrobial Agents and Chemotherapy, 1979
- A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.Journal of the American Pharmaceutical Association (Scientific ed.), 1957